Does the APOE genotype influence the rate of global cognitive decline (CDR-SOB)
  
   Lead Investigator:    Alberto Serrano-Pozo
   Institution      :    Massachusetts ADRC
   E-Mail           :    aserrano1@mgh.harvard.edu
   Proposal ID      :    890



   Proposal Description:
   Does the APOE genotype influence the rate of global cognitive decline (CDR-SOB) in dementia due to Alzheimer?s disease (AD)? Does the APOE genotype impact the rate of decline of any cognitive domain (memory, attention, executive function, language) independently of its effects on AD neuropathological change? We plan to answer these questions using a reverse-time longitudinal modeling approach in conjunction with latent class estimation to adjust for unmeasured sources of heterogeneity.